pentobarbital will decrease the level or effect of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will increase the amount or influence of clopidogrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Minimal (1)pentobarbital will lower the extent or result of paclitaxel protein sure by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Not known.
Contraindicated (1)pentobarbital will minimize the level or effect of dienogest/estradiol valerate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Females shouldn't choose estradiol valerate/dienogest as their contraceptive when making use of strong CYP3A4 inducers resulting from prospective minimize in contraceptive efficacy.
pentobarbital will lessen the level or outcome of repaglinide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will decrease the level or result of parecoxib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unfamiliar.
pentobarbital will decrease the extent or result of estropipate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
Purchasing drug concentrations in the blood or urine, proper laboratory assessments, and imaging from the emergency department.
pentobarbital will lessen the level or outcome of tinidazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital will minimize the level or outcome of duvelisib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration with a powerful CYP3A inducer decreases duvelisib area underneath the curve (AUC), which may decrease duvelisib efficacy.
pentobarbital will decrease the extent or effect of ibuprofen by impacting hepatic enzyme CYP2C9/10 metabolism. Minimal/Significance Not known.
pentobarbital will lower the extent or result of alosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unknown.
Apply evidence-centered recommendations and detailed understanding of pentobarbital's pharmacology, pharmacokinetics, and probable drug interactions with the Protected and helpful utilization of pentobarbital.
Pentobarbital interacts with various major courses of prescription drugs and demands shut monitoring to keep up here therapeutic drug concentrations. As a class, barbiturates induce hepatic microsomal enzymes, which raise the level of metabolism of other medication metabolized by these hepatic enzymes.